LoveCraft's World 3 by Lamuserie
Lamuserie created this incredible Lovecraft creature as a promo render for Sixus1 (he's doing a series of tutorials at Renderosity). Now, if you know Lovecraft you'll especially enjoy this "old god" image, but even if you don't the image is still extremely creepy. A bit like Wayne Barlow's work, but uniquely his own, Lamuserie created a creature who is in mid-action. Is the viewer being attacked? Is the creature crying out a warning? The colors and the plethora of eyes also add to the overall effect of the uncanny. And then there's that awful idea that this creature is part human.
Check out Lamuserie's gallery at Renderosity which has dozens of images that will stay in your head.